MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

The MDM2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out p53-independent functions. Here we report that MDM2 is required for the efficient generation of induced pluripotent stem cells (iPSCs) from murine embryonic fibroblasts, in the absence of p53. Similarly, MDM2 depletion in...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Mol Cell
Auteurs principaux: Wienken, Magdalena, Dickmanns, Antje, Nemajerova, Alice, Kramer, Daniela, Najafova, Zeynab, Weiss, Miriam, Karpiuk, Oleksandra, Kassem, Moustapha, Zhang, Yanping, Lozano, Guillermina, Johnsen, Steven A., Moll, Ute M., Zhang, Xin, Dobbelstein, Matthias
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284523/
https://ncbi.nlm.nih.gov/pubmed/26748827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.12.008
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires