MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

The MDM2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out p53-independent functions. Here we report that MDM2 is required for the efficient generation of induced pluripotent stem cells (iPSCs) from murine embryonic fibroblasts, in the absence of p53. Similarly, MDM2 depletion in...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Wienken, Magdalena, Dickmanns, Antje, Nemajerova, Alice, Kramer, Daniela, Najafova, Zeynab, Weiss, Miriam, Karpiuk, Oleksandra, Kassem, Moustapha, Zhang, Yanping, Lozano, Guillermina, Johnsen, Steven A., Moll, Ute M., Zhang, Xin, Dobbelstein, Matthias
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284523/
https://ncbi.nlm.nih.gov/pubmed/26748827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.12.008
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