vWA proteins of Leptospira interrogans induce hemorrhage in leptospirosis by competitive inhibition of vWF/GPIb-mediated platelet aggregation

BACKGROUD: Leptospira interrogans is the major causative agent of leptospirosis, a worldwide zoonotic disease. Hemorrhage is a typical pathological feature of leptospirosis. Binding of von Willebrand factor (vWF) to platelet glycoprotein-Ibα (GPIbα) is a crucial step in initiation of platelet aggreg...

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Udgivet i:EBioMedicine
Main Authors: Fang, Jia-Qi, Imran, Muhammad, Hu, Wei-Lin, Ojcius, David M., Li, Yang, Ge, Yu-Mei, Li, Kai-Xuan, Lin, Xu'ai, Yan, Jie
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
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Research paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284457/
https://ncbi.nlm.nih.gov/pubmed/30337247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.10.033
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