Inactivation of Cancer Mutations Utilizing CRISPR/Cas9

Although whole-genome sequencing has uncovered a large number of mutations that drive tumorigenesis, functional ratification for most mutations remains sparse. Here, we present an approach to test functional relevance of tumor mutations employing CRISPR/Cas9. Combining comprehensive sgRNA design and...

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Bibliografiske detaljer
Udgivet i:J Natl Cancer Inst
Main Authors: Gebler, Christina, Lohoff, Tim, Paszkowski-Rogacz, Maciej, Mircetic, Jovan, Chakraborty, Debojyoti, Camgoz, Aylin, Hamann, Martin V, Theis, Mirko, Thiede, Christian, Buchholz, Frank
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Brief Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284257/
https://ncbi.nlm.nih.gov/pubmed/27576906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djw183
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