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Development of a genetic sensor that eliminates p53 deficient cells

The TP53 gene fulfills a central role in protecting cells from genetic insult. Given this crucial role it might be surprising that p53 itself is not essential for cell survival. Indeed, TP53 is the single most mutated gene across different cancer types. Thus, both a theoretical and a question of sig...

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Pubblicato in:Nat Commun
Autori principali: Mircetic, Jovan, Dietrich, Antje, Paszkowski-Rogacz, Maciej, Krause, Mechthild, Buchholz, Frank
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684360/
https://ncbi.nlm.nih.gov/pubmed/29133879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01688-w
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