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Development of a genetic sensor that eliminates p53 deficient cells

The TP53 gene fulfills a central role in protecting cells from genetic insult. Given this crucial role it might be surprising that p53 itself is not essential for cell survival. Indeed, TP53 is the single most mutated gene across different cancer types. Thus, both a theoretical and a question of sig...

詳細記述

保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Mircetic, Jovan, Dietrich, Antje, Paszkowski-Rogacz, Maciej, Krause, Mechthild, Buchholz, Frank
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684360/
https://ncbi.nlm.nih.gov/pubmed/29133879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01688-w
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