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Development of a genetic sensor that eliminates p53 deficient cells

The TP53 gene fulfills a central role in protecting cells from genetic insult. Given this crucial role it might be surprising that p53 itself is not essential for cell survival. Indeed, TP53 is the single most mutated gene across different cancer types. Thus, both a theoretical and a question of sig...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Mircetic, Jovan, Dietrich, Antje, Paszkowski-Rogacz, Maciej, Krause, Mechthild, Buchholz, Frank
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684360/
https://ncbi.nlm.nih.gov/pubmed/29133879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01688-w
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