A rapid fluorescent indicator displacement assay and principal component/cluster data analysis for determination of ligand–nucleic acid structural selectivity

We describe a rapid fluorescence indicator displacement assay (R-FID) to evaluate the affinity and the selectivity of compounds binding to different DNA structures. We validated the assay using a library of 30 well-known nucleic acid binders containing a variety chemical scaffolds. We used a combina...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Nucleic Acids Res
Asıl Yazarlar: del Villar-Guerra, Rafael, Gray, Robert D, Trent, John O, Chaires, Jonathan B
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2018
Konular:
Methods Online
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283418/
https://ncbi.nlm.nih.gov/pubmed/29361140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky019
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller