Small molecule inhibitors of metabolic enzymes repurposed as a new class of anthelmintics

The enormous prevalence of infections caused by parasitic nematodes worldwide, coupled to the rapid emergence of their resistance to commonly used anthelmintic drugs, presents an urgent need for the discovery of new drugs. Herein, we have identified several classes of small molecules with broad spec...

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Publicat a:ACS Infect Dis
Autors principals: Tyagi, Rahul, Maddirala, Amarendar Reddy, Elfawal, Mostafa, Fischer, Chelsea, Bulman, Christina A., Rosa, Bruce A., Gao, Xin, Chugani, Ryan, Zhou, Mingzhou, Helander, Jon, Brindley, Paul J., Tseng, Chih-Chung, Greig, Iain R., Sakanari, Judy, Wildman, Scott A., Aroian, Raffi, Janetka, James W., Mitreva, Makedonka
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283408/
https://ncbi.nlm.nih.gov/pubmed/29718656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00090
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