Small molecule inhibitors of metabolic enzymes repurposed as a new class of anthelmintics

The enormous prevalence of infections caused by parasitic nematodes worldwide, coupled to the rapid emergence of their resistance to commonly used anthelmintic drugs, presents an urgent need for the discovery of new drugs. Herein, we have identified several classes of small molecules with broad spec...

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Publicado en:ACS Infect Dis
Main Authors: Tyagi, Rahul, Maddirala, Amarendar Reddy, Elfawal, Mostafa, Fischer, Chelsea, Bulman, Christina A., Rosa, Bruce A., Gao, Xin, Chugani, Ryan, Zhou, Mingzhou, Helander, Jon, Brindley, Paul J., Tseng, Chih-Chung, Greig, Iain R., Sakanari, Judy, Wildman, Scott A., Aroian, Raffi, Janetka, James W., Mitreva, Makedonka
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283408/
https://ncbi.nlm.nih.gov/pubmed/29718656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00090
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