Quantitative Analysis of the Brain Ubiquitylome in Alzheimer’s Disease

Several neurodegenerative diseases including Alzheim er’s Disease (AD) are characterized by ubiquitin-positive pathological protein aggregates. Here, an immunoaffinity approach is utilized to enrich ubiquitylated isopeptides after trypsin digestion from five AD and five age-matched control postmorte...

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Pubblicato in:Proteomics
Autori principali: Abreha, Measho H., Dammer, Eric B., Ping, Lingyan, Zhang, Tian, Duong, Duc M., Gearing, Marla, Lah, James J., Levey, Allan I., Seyfried, Nicholas T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6283072/
https://ncbi.nlm.nih.gov/pubmed/30230243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201800108
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