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Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations

Inherited mitochondrial DNA (mtDNA) mutations cause mitochondrial disease, but mtDNA mutations also occur somatically and accumulate during ageing. Studies have shown that the mutation load of some inherited mtDNA mutations decreases over time in blood, suggesting selection against the mutation. How...

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Bibliografske podrobnosti
izdano v:J Pathol
Main Authors: Su, Tianhong, Grady, John P, Afshar, Sorena, McDonald, Stuart AC, Taylor, Robert W, Turnbull, Doug M, Greaves, Laura C
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Ltd 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282723/
https://ncbi.nlm.nih.gov/pubmed/30146801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5156
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