Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations

Inherited mitochondrial DNA (mtDNA) mutations cause mitochondrial disease, but mtDNA mutations also occur somatically and accumulate during ageing. Studies have shown that the mutation load of some inherited mtDNA mutations decreases over time in blood, suggesting selection against the mutation. How...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Su, Tianhong, Grady, John P, Afshar, Sorena, McDonald, Stuart AC, Taylor, Robert W, Turnbull, Doug M, Greaves, Laura C
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2018
Assuntos:
Brief Definitive Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282723/
https://ncbi.nlm.nih.gov/pubmed/30146801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5156
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