Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations

Inherited mitochondrial DNA (mtDNA) mutations cause mitochondrial disease, but mtDNA mutations also occur somatically and accumulate during ageing. Studies have shown that the mutation load of some inherited mtDNA mutations decreases over time in blood, suggesting selection against the mutation. How...

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Dettagli Bibliografici
Pubblicato in:J Pathol
Autori principali: Su, Tianhong, Grady, John P, Afshar, Sorena, McDonald, Stuart AC, Taylor, Robert W, Turnbull, Doug M, Greaves, Laura C
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Ltd 2018
Soggetti:
Brief Definitive Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282723/
https://ncbi.nlm.nih.gov/pubmed/30146801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5156
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