TLR7‐let‐7 Signaling Contributes to Ethanol‐Induced Hepatic Inflammatory Response in Mice and in Alcoholic Hepatitis

BACKGROUND: Toll‐like receptor 7 (TLR7) is an endosomal TLR that is activated by single‐stranded RNA, including endogenous microRNAs (e.g., let‐7b). Increased hepatic expression of TLRs, microRNAs, and inflammatory mediators is linked to ethanol (EtOH) exposure and to alcoholic liver disease (ALD)....

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Vydáno v:Alcohol Clin Exp Res
Hlavní autoři: Massey, Veronica L., Qin, Liya, Cabezas, Joaquin, Caballeria, Juan, Sancho‐Bru, Pau, Bataller, Ramon, Crews, Fulton T.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Pathology, Immunology and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282707/
https://ncbi.nlm.nih.gov/pubmed/30103265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.13871
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