Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis

BACKGROUND & AIMS: Transdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in the pathogenesis of liver fibrosis. Transforming growth factor β (TGF-β) and platelet-derived growth factor (PDGF) are canonical HSC activators after liver injury. The aim of this study...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Mol Gastroenterol Hepatol
Prif Awduron: Martin-Mateos, Rosa, De Assuncao, Thiago M., Arab, Juan Pablo, Jalan-Sakrikar, Nidhi, Yaqoob, Usman, Greuter, Thomas, Verma, Vikas K., Mathison, Angela J., Cao, Sheng, Lomberk, Gwen, Mathurin, Philippe, Urrutia, Raul, Huebert, Robert C., Shah, Vijay H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2018
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282644/
https://ncbi.nlm.nih.gov/pubmed/30539787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.09.005
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