A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

The complement system is an efficient anti-microbial effector mechanism. On the other hand abnormal complement activation is involved in the pathogenesis of multiple inflammatory and hemolytic diseases. As general inhibition of the complement system may jeopardize patient health due to increased sus...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Yatime, Laure, Merle, Nicolas S., Hansen, Annette G., Friis, Niels Anton, Østergaard, Jakob A., Bjerre, Mette, Roumenina, Lubka T., Thiel, Steffen, Kristensen, Peter, Andersen, Gregers R.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281825/
https://ncbi.nlm.nih.gov/pubmed/30555486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02822
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