Hydrogen-deuterium exchange coupled to top- and middle-down mass spectrometry reveals histone tail dynamics before and after nucleosome assembly

Until recently, a major limitation of hydrogen deuterium exchange mass spectrometry (HDX-MS) was that resolution of deuterium localization was limited to the length of the peptide generated during proteolysis. However, electron transfer dissociation (ETD) has been shown to preserve deuterium label i...

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Foilsithe in:Structure
Main Authors: Karch, Kelly R., Coradin, Mariel, Zandarashvili, Levani, Kan, Zhong-Yuan, Gerace, Morgan, Englander, S. Walter, Black, Ben E., Garcia, Benjamin A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281757/
https://ncbi.nlm.nih.gov/pubmed/30293810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.08.006
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