Induction of immunosuppressive functions and NF-κB by FLIP in monocytes

Immunosuppression is a hallmark of tumor progression, and treatments that inhibit or deplete monocytic myeloid-derived suppressive cells could promote anti-tumor immunity. c-FLIP is a central regulator of caspase-8-mediated apoptosis and necroptosis. Here we show that low-dose cytotoxic chemotherapy...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Fiore, Alessandra, Ugel, Stefano, De Sanctis, Francesco, Sandri, Sara, Fracasso, Giulio, Trovato, Rosalinda, Sartoris, Silvia, Solito, Samantha, Mandruzzato, Susanna, Vascotto, Fulvia, Hippen, Keli L., Mondanelli, Giada, Grohmann, Ursula, Piro, Geny, Carbone, Carmine, Melisi, Davide, Lawlor, Rita T., Scarpa, Aldo, Lamolinara, Alessia, Iezzi, Manuela, Fassan, Matteo, Bicciato, Silvio, Blazar, Bruce R., Sahin, Ugur, Murray, Peter J., Bronte, Vincenzo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281604/
https://ncbi.nlm.nih.gov/pubmed/30518925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07654-4
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