Induction of immunosuppressive functions and NF-κB by FLIP in monocytes

Immunosuppression is a hallmark of tumor progression, and treatments that inhibit or deplete monocytic myeloid-derived suppressive cells could promote anti-tumor immunity. c-FLIP is a central regulator of caspase-8-mediated apoptosis and necroptosis. Here we show that low-dose cytotoxic chemotherapy...

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Publicado no:Nat Commun
Main Authors: Fiore, Alessandra, Ugel, Stefano, De Sanctis, Francesco, Sandri, Sara, Fracasso, Giulio, Trovato, Rosalinda, Sartoris, Silvia, Solito, Samantha, Mandruzzato, Susanna, Vascotto, Fulvia, Hippen, Keli L., Mondanelli, Giada, Grohmann, Ursula, Piro, Geny, Carbone, Carmine, Melisi, Davide, Lawlor, Rita T., Scarpa, Aldo, Lamolinara, Alessia, Iezzi, Manuela, Fassan, Matteo, Bicciato, Silvio, Blazar, Bruce R., Sahin, Ugur, Murray, Peter J., Bronte, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281604/
https://ncbi.nlm.nih.gov/pubmed/30518925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07654-4
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