Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with an overall 5-year survival rate of less than 8%. New evidence indicates that PDAC cells release pro-inflammatory metabolites that induce a marked alteration of normal hematopoiesis, favoring the expansion and ac...

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Bibliographic Details
Published in:J Immunother Cancer
Main Authors: Trovato, Rosalinda, Fiore, Alessandra, Sartori, Sara, Canè, Stefania, Giugno, Rosalba, Cascione, Luciano, Paiella, Salvatore, Salvia, Roberto, De Sanctis, Francesco, Poffe, Ornella, Anselmi, Cristina, Hofer, Francesca, Sartoris, Silvia, Piro, Geny, Carbone, Carmine, Corbo, Vincenzo, Lawlor, Rita, Solito, Samantha, Pinton, Laura, Mandruzzato, Susanna, Bassi, Claudio, Scarpa, Aldo, Bronte, Vincenzo, Ugel, Stefano
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6751612/
https://ncbi.nlm.nih.gov/pubmed/31533831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0734-6
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