L159F and V321A Sofosbuvir-Associated Hepatitis C Virus NS5B Substitutions

Background. Sofosbuvir (SOF) exhibits a high barrier to resistance, with no S282T NS5B substitution or phenotypic resistance detected in phase 3 registration studies. Methods. Here, emergence of the NS5B variants L159F and V321A and possible association with resistance was evaluated in 8 studies of...

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Detalles Bibliográficos
Publicado en:J Infect Dis
Autores principales: Svarovskaia, Evguenia S., Gane, Edward, Dvory-Sobol, Hadas, Martin, Ross, Doehle, Brian, Hedskog, Charlotte, Jacobson, Ira M., Nelson, David R., Lawitz, Eric, Brainard, Diana M., McHutchison, John G., Miller, Michael D., Mo, Hongmei
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
Materias:
Major Articles and Brief Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281391/
https://ncbi.nlm.nih.gov/pubmed/26603202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv564
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