The emergence of NS5B resistance associated substitution S282T after sofosbuvir‐based treatment

S282T in NS5B is the primary amino acid substitution associated with resistance to sofosbuvir (SOF) but has rarely been detected in patients treated with a SOF‐based regimen. Here, the emergence and fitness of the S282T substitution in virologic failure patients administered SOF‐based regimens acros...

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Vydáno v:Hepatol Commun
Hlavní autoři: Gane, Edward J., Metivier, Sophie, Nahass, Ronald, Ryan, Michael, Stedman, Catherine A., Svarovskaia, Evguenia S., Mo, Hongmei, Doehle, Brian, Dvory‐Sobol, Hadas, Hedskog, Charlotte, Lin, Ming, Brainard, Diana M., Yang, Jenny C., McHutchison, John G., Sulkowski, Mark, Younes, Ziad, Lawitz, Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678900/
https://ncbi.nlm.nih.gov/pubmed/29404477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1060
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