Mutation T74S in HIV-1 subtype B and C proteases resensitizes them to ritonavir and indinavir and confers fitness advantage

OBJECTIVES: Several drug resistance and secondary mutations have been described in HIV-1 viruses from patients undergoing antiretroviral therapy. In this study, we assessed the impact of the protease substitution T74S on the phenotype and on the replicative fitness in HIV-1 subtypes B and C. METHODS...

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Foilsithe in:J Antimicrob Chemother
Main Authors: Soares, Esmeralda A., Santos, André F., Gonzalez, Luis M., Lalonde, Matthew S., Tebit, Denis M., Tanuri, Amilcar, Arts, Eric J., Soares, Marcelo A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2009
Ábhair:
Original Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281354/
https://ncbi.nlm.nih.gov/pubmed/19710076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkp315
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