Impact of Nelfinavir Resistance Mutations on In Vitro Phenotype, Fitness, and Replication Capacity of Human Immunodeficiency Virus Type 1 with Subtype B and C Proteases

Human immunodeficiency virus type 1 subtype B and C proteases were manipulated to contain 90M, 88D, or 89L, and their in vitro biological properties were studied. We showed that D30N has significantly more impact in subtype C than in subtype B counterparts, accounting for the reported low prevalence...

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Detalhes bibliográficos
Main Authors: Gonzalez, Luis M. F., Brindeiro, Rodrigo M., Aguiar, Renato S., Pereira, Helena S., Abreu, Celina M., Soares, Marcelo A., Tanuri, Amilcar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC514783/
https://ncbi.nlm.nih.gov/pubmed/15328124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.9.3552-3555.2004
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