Impact of Nelfinavir Resistance Mutations on In Vitro Phenotype, Fitness, and Replication Capacity of Human Immunodeficiency Virus Type 1 with Subtype B and C Proteases

Human immunodeficiency virus type 1 subtype B and C proteases were manipulated to contain 90M, 88D, or 89L, and their in vitro biological properties were studied. We showed that D30N has significantly more impact in subtype C than in subtype B counterparts, accounting for the reported low prevalence...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Antimicrob Agents Chemother
Egile Nagusiak: Gonzalez, Luis M. F., Brindeiro, Rodrigo M., Aguiar, Renato S., Pereira, Helena S., Abreu, Celina M., Soares, Marcelo A., Tanuri, Amilcar
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology (ASM) 2004
Gaiak:
Antiviral Agents
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514783/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15328124/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.9.3552-3555.2004
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