Trypanosoma cruzi-specific IFN-γ-producing cells in chronic Chagas disease associate with a functional IL-7/IL-7R axis

BACKGROUND: The severity of cardiac disease in chronic Chagas disease patients is associated with different features of T-cell exhaustion. Here, we assessed whether the ability of T cells to secrete IFN-γ in response to T. cruzi was linked to disruption in immune homeostasis and inflammation in pati...

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Библиографические подробности
Опубликовано в: :PLoS Negl Trop Dis
Главные авторы: Natale, María A., César, Gonzalo A., Alvarez, María G., Castro Eiro, Melisa D., Lococo, Bruno, Bertocchi, Graciela, Albareda, María C., Laucella, Susana A.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2018
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6281225/
https://ncbi.nlm.nih.gov/pubmed/30517089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0006998
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