Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro

In chronic Chagas disease, Trypanosoma cruzi-specific T-cell function decreases over time, and alterations in the homeostatic IL-7/IL-7R axis are evident, consistent with a process of immune exhaustion. IL-27 is an important immunoregulatory cytokine that shares T-cell signaling with IL-7 and other...

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Publicado en:PLoS Negl Trop Dis
Autores principales: Natale, María Ailén, Minning, Todd, Albareda, María Cecilia, Castro Eiro, Melisa Daiana, Álvarez, María Gabriela, Lococo, Bruno, Cesar, Gonzalo, Bertocchi, Graciela, Elias, María Josefina, Caputo, María Belén, Tarleton, Rick Lee, Laucella, Susana Adriana
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195349/
https://ncbi.nlm.nih.gov/pubmed/34061845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0009473
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