Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro

In chronic Chagas disease, Trypanosoma cruzi-specific T-cell function decreases over time, and alterations in the homeostatic IL-7/IL-7R axis are evident, consistent with a process of immune exhaustion. IL-27 is an important immunoregulatory cytokine that shares T-cell signaling with IL-7 and other...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Negl Trop Dis
Egile Nagusiak: Natale, María Ailén, Minning, Todd, Albareda, María Cecilia, Castro Eiro, Melisa Daiana, Álvarez, María Gabriela, Lococo, Bruno, Cesar, Gonzalo, Bertocchi, Graciela, Elias, María Josefina, Caputo, María Belén, Tarleton, Rick Lee, Laucella, Susana Adriana
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2021
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195349/
https://ncbi.nlm.nih.gov/pubmed/34061845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0009473
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