Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro

In chronic Chagas disease, Trypanosoma cruzi-specific T-cell function decreases over time, and alterations in the homeostatic IL-7/IL-7R axis are evident, consistent with a process of immune exhaustion. IL-27 is an important immunoregulatory cytokine that shares T-cell signaling with IL-7 and other...

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Vydáno v:PLoS Negl Trop Dis
Hlavní autoři: Natale, María Ailén, Minning, Todd, Albareda, María Cecilia, Castro Eiro, Melisa Daiana, Álvarez, María Gabriela, Lococo, Bruno, Cesar, Gonzalo, Bertocchi, Graciela, Elias, María Josefina, Caputo, María Belén, Tarleton, Rick Lee, Laucella, Susana Adriana
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195349/
https://ncbi.nlm.nih.gov/pubmed/34061845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0009473
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