Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes

Mosaic mutations present in the germline have important implications for reproductive risk and disease transmission. We previously demonstrated a phenomenon occurring in the male germline, whereby specific mutations arising spontaneously in stem cells (spermatogonia) lead to clonal expansion, result...

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Bibliografische gegevens
Gepubliceerd in:Genome Res
Hoofdauteurs: Maher, Geoffrey J., Ralph, Hannah K., Ding, Zhihao, Koelling, Nils, Mlcochova, Hana, Giannoulatou, Eleni, Dhami, Pawan, Paul, Dirk S., Stricker, Stefan H., Beck, Stephan, McVean, Gilean, Wilkie, Andrew O.M., Goriely, Anne
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2018
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280762/
https://ncbi.nlm.nih.gov/pubmed/30355600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.239186.118
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