Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes

Mosaic mutations present in the germline have important implications for reproductive risk and disease transmission. We previously demonstrated a phenomenon occurring in the male germline, whereby specific mutations arising spontaneously in stem cells (spermatogonia) lead to clonal expansion, result...

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Veröffentlicht in:Genome Res
Hauptverfasser: Maher, Geoffrey J., Ralph, Hannah K., Ding, Zhihao, Koelling, Nils, Mlcochova, Hana, Giannoulatou, Eleni, Dhami, Pawan, Paul, Dirk S., Stricker, Stefan H., Beck, Stephan, McVean, Gilean, Wilkie, Andrew O.M., Goriely, Anne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280762/
https://ncbi.nlm.nih.gov/pubmed/30355600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.239186.118
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