Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes

Mosaic mutations present in the germline have important implications for reproductive risk and disease transmission. We previously demonstrated a phenomenon occurring in the male germline, whereby specific mutations arising spontaneously in stem cells (spermatogonia) lead to clonal expansion, result...

詳細記述

保存先:
書誌詳細
出版年:Genome Res
主要な著者: Maher, Geoffrey J., Ralph, Hannah K., Ding, Zhihao, Koelling, Nils, Mlcochova, Hana, Giannoulatou, Eleni, Dhami, Pawan, Paul, Dirk S., Stricker, Stefan H., Beck, Stephan, McVean, Gilean, Wilkie, Andrew O.M., Goriely, Anne
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory Press 2018
主題:
Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280762/
https://ncbi.nlm.nih.gov/pubmed/30355600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.239186.118
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