Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection

While genetic variants are known to be associated with overall gene abundance in stimulated immune cells, less is known about their effects on alternative isoform usage. By analyzing RNA-seq profiles of monocyte-derived dendritic cells from 243 individuals, we uncovered thousands of unannotated isof...

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Veröffentlicht in:Genome Res
Hauptverfasser: Ye, Chun Jimmie, Chen, Jenny, Villani, Alexandra-Chloé, Gate, Rachel E., Subramaniam, Meena, Bhangale, Tushar, Lee, Mark N., Raj, Towfique, Raychowdhury, Raktima, Li, Weibo, Rogel, Noga, Simmons, Sean, Imboywa, Selina H., Chipendo, Portia I., McCabe, Cristin, Lee, Michelle H., Frohlich, Irene Y., Stranger, Barbara E., De Jager, Philip L., Regev, Aviv, Behrens, Tim, Hacohen, Nir
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2018
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280757/
https://ncbi.nlm.nih.gov/pubmed/30446528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.240390.118
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