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DIG-seq: a genome-wide CRISPR off-target profiling method using chromatin DNA
To investigate whether and how CRISPR-Cas9 on-target and off-target activities are affected by chromatin in eukaryotic cells, we first identified a series of identical endogenous DNA sequences present in both open and closed chromatin regions and then measured mutation frequencies at these sites in...
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| Pubblicato in: | Genome Res |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6280750/ https://ncbi.nlm.nih.gov/pubmed/30413470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.236620.118 |
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