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Protect-seq: genome-wide profiling of nuclease inaccessible domains reveals physical properties of chromatin

In metazoan cell nuclei, heterochromatin constitutes large chromatin domains that are in close contact with the nuclear lamina. These heterochromatin/lamina-associated domains (LADs) domains are difficult to profile and warrants a simpler and direct method. Here we report a new method, Protect-seq,...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Spracklin, George, Pradhan, Sriharsa
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026637/
https://ncbi.nlm.nih.gov/pubmed/31819993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1150
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