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Asymmetric Synthesis of Aminochromanes via Intramolecular Indium-Mediated Allylation of Chiral Hydrazones

The asymmetric intramolecular indium-mediated cyclization reaction delivers chromanes with excellent diastereoselectivity (68–91% yield, dr >99:1). The reaction was efficient for aryl substrates with both electron withdrawing or donating groups. Carboxylic acid additives were found to be necessar...

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Détails bibliographiques
Publié dans:J Org Chem
Auteurs principaux: Samanta, Debasis, Kargbo, Robert B., Cook, Gregory R.
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6280656/
https://ncbi.nlm.nih.gov/pubmed/19702255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo901195g
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