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Catalytic Asymmetric Synthesis of Diketopiperazines by Intramolecular Tsuji–Trost Allylation

[Image: see text] We report the intramolecular Tsuji–Trost reaction of Ugi adducts to give spiro-diketopiperazines in high yield and with high enantioselectivity. This approach allows the catalytic asymmetric construction of a broad range of these medicinally important heterocycles under mild condit...

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書目詳細資料
發表在:J Org Chem
Main Authors: Faltracco, Matteo, Cotogno, Silvia, Vande Velde, Christophe M. L., Ruijter, Eelco
格式: Artigo
語言:Inglês
出版: American Chemical Society 2019
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760471/
https://ncbi.nlm.nih.gov/pubmed/31446758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b01994
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