Indoxyl Sulfate Promotes Arterial Thrombosis in Rat Model via Increased Levels of Complex TF/VII, PAI-1, Platelet Activation as Well as Decreased Contents of SIRT1 and SIRT3

Patients suffering from chronic kidney disease (CKD) are at a 20-fold higher risk of dying due to cardiovascular diseases (CVDs), primarily thrombosis following vascular injury. CKD is connected with retention of uremic toxins, especially indoxyl sulfate (IS), which are currently considered as a non...

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Bibliographic Details
Published in:Front Physiol
Main Authors: Karbowska, Malgorzata, Kaminski, Tomasz W., Znorko, Beata, Domaniewski, Tomasz, Misztal, Tomasz, Rusak, Tomasz, Pryczynicz, Anna, Guzinska-Ustymowicz, Katarzyna, Pawlak, Krystyna, Pawlak, Dariusz
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279869/
https://ncbi.nlm.nih.gov/pubmed/30546314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01623
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