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Management of Patients with Acute Methotrexate Nephrotoxicity with High-Dose Leucovorin

BACKGROUND: Acute kidney injury complicating high-dose methotrexate therapy increases the risk for severe mucositis, myelosuppression, and death. It is unclear whether high-dose leucovorin and supportive therapy without the use of glucarpidase can reduce toxicity from high-dose methotrexate. STUDY D...

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Bibliografische gegevens
Gepubliceerd in:Pharmacotherapy
Hoofdauteurs: Flombaum, Carlos D., Liu, Dazhi, Yan, Shirley Qiong, Chan, Amelia, Mathew, Sherry, Meyers, Paul A., Glezerman, Ilya G., Muthukumar, Thangamani
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279619/
https://ncbi.nlm.nih.gov/pubmed/29863765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/phar.2145
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