Clinically relevant and minimally invasive tumor surveillance of pediatric diffuse midline gliomas using patient derived liquid biopsy

PURPOSE: Pediatric DMGs are highly malignant tumors with poor clinical outcomes. Over 70% of DMG patients harbor the histone 3 p.K27M (H3K27M) mutation, which correlates with a poorer clinical outcome, and is also used as a criterion for enrollment in clinical trials. Because complete surgical resec...

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Pubblicato in:Clin Cancer Res
Autori principali: Panditharatna, Eshini, Kilburn, Lindsay B., Aboian, Mariam S., Kambhampati, Madhuri, Gordish-Dressman, Heather, Magge, Suresh N., Gupta, Nalin, Myseros, John S., Hwang, Eugene I., Kline, Cassie, Crawford, John R., Warren, Katherine E., Cha, Soonmee, Liang, Winnie S., Berens, Michael E., Packer, Roger J., Resnick, Adam C., Prados, Michael, Mueller, Sabine, Nazarian, Javad
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279526/
https://ncbi.nlm.nih.gov/pubmed/30322880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1345
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