Clinically relevant and minimally invasive tumor surveillance of pediatric diffuse midline gliomas using patient derived liquid biopsy

PURPOSE: Pediatric DMGs are highly malignant tumors with poor clinical outcomes. Over 70% of DMG patients harbor the histone 3 p.K27M (H3K27M) mutation, which correlates with a poorer clinical outcome, and is also used as a criterion for enrollment in clinical trials. Because complete surgical resec...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Panditharatna, Eshini, Kilburn, Lindsay B., Aboian, Mariam S., Kambhampati, Madhuri, Gordish-Dressman, Heather, Magge, Suresh N., Gupta, Nalin, Myseros, John S., Hwang, Eugene I., Kline, Cassie, Crawford, John R., Warren, Katherine E., Cha, Soonmee, Liang, Winnie S., Berens, Michael E., Packer, Roger J., Resnick, Adam C., Prados, Michael, Mueller, Sabine, Nazarian, Javad
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279526/
https://ncbi.nlm.nih.gov/pubmed/30322880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1345
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