Clinically relevant and minimally invasive tumor surveillance of pediatric diffuse midline gliomas using patient derived liquid biopsy

PURPOSE: Pediatric DMGs are highly malignant tumors with poor clinical outcomes. Over 70% of DMG patients harbor the histone 3 p.K27M (H3K27M) mutation, which correlates with a poorer clinical outcome, and is also used as a criterion for enrollment in clinical trials. Because complete surgical resec...

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Udgivet i:Clin Cancer Res
Main Authors: Panditharatna, Eshini, Kilburn, Lindsay B., Aboian, Mariam S., Kambhampati, Madhuri, Gordish-Dressman, Heather, Magge, Suresh N., Gupta, Nalin, Myseros, John S., Hwang, Eugene I., Kline, Cassie, Crawford, John R., Warren, Katherine E., Cha, Soonmee, Liang, Winnie S., Berens, Michael E., Packer, Roger J., Resnick, Adam C., Prados, Michael, Mueller, Sabine, Nazarian, Javad
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279526/
https://ncbi.nlm.nih.gov/pubmed/30322880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1345
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