Low-dose cyclophosphamide depletes circulating naïve and activated regulatory T cells in malignant pleural mesothelioma patients synergistically treated with dendritic cell-based immunotherapy

Rationale: Regulatory T cells (Treg) play a pivotal role in the immunosuppressive tumor micro-environment in cancer, including mesothelioma. Recently, the combination of autologous tumor lysate-pulsed dendritic cells (DC) and metronomic cyclophosphamide (mCTX) was reported as a feasible and well-tol...

詳細記述

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書誌詳細
出版年:Oncoimmunology
主要な著者: Noordam, Lisanne, Kaijen, Margaretha E.H., Bezemer, Koen, Cornelissen, Robin, Maat, Lex A.P.W.M., Hoogsteden, Henk C., Aerts, Joachim G.J.V., Hendriks, Rudi W., Hegmans, Joost P.J.J, Vroman, Heleen
フォーマット: Artigo
言語:Inglês
出版事項: Taylor & Francis 2018
主題:
Original Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279421/
https://ncbi.nlm.nih.gov/pubmed/30524884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1474318
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