A Dectin-1-Caspase-8 Pathway Licenses Canonical Caspase-1 Inflammasome Activation and Interleukin-1β Release in Response to a Pathogenic Fungus

BACKGROUND: Paracoccidioides brasiliensis is equipped with an arsenal of virulence factors that are crucial for causing infection. Our group previously defined the NLRP3 inflammasome as a mediator of P brasiliensis-induced cell damage recognition and induction of effective Th1 immune responses. Howe...

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Bibliografiske detaljer
Udgivet i:J Infect Dis
Main Authors: Ketelut-Carneiro, Natália, Ghosh, Sreya, Levitz, Stuart M, Fitzgerald, Katherine A, da Silva, João Santana
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Major Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279136/
https://ncbi.nlm.nih.gov/pubmed/29099934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix568
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