Targeting Endothelial Erk1/2-Akt Axis as a Regeneration Strategy to Bypass Fibrosis during Chronic Liver Injury in Mice

Liver sinusoidal endothelial cells (LSECs) have great capacity for liver regeneration, and this capacity can easily switch to profibrotic phenotype, which is still poorly understood. In this study, we elucidated a potential target in LSECs for regenerative treatment that can bypass fibrosis during c...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Lao, Yuanxiang, Li, Yanyan, Zhang, Ping, Shao, Qianqian, Lin, Weiran, Qiu, Bintao, Lv, Yongzhuang, Tang, Lichun, Su, Shishuai, Zhang, Hongyu, Tian, Chunyan, Sun, Aihua, Wei, Handong, Zhang, Pumin, Wu, Yan, Jiang, Ying, He, Fuchu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277559/
https://ncbi.nlm.nih.gov/pubmed/30266653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.08.016
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