Targeting Endothelial Erk1/2-Akt Axis as a Regeneration Strategy to Bypass Fibrosis during Chronic Liver Injury in Mice

Liver sinusoidal endothelial cells (LSECs) have great capacity for liver regeneration, and this capacity can easily switch to profibrotic phenotype, which is still poorly understood. In this study, we elucidated a potential target in LSECs for regenerative treatment that can bypass fibrosis during c...

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Publicat a:Mol Ther
Autors principals: Lao, Yuanxiang, Li, Yanyan, Zhang, Ping, Shao, Qianqian, Lin, Weiran, Qiu, Bintao, Lv, Yongzhuang, Tang, Lichun, Su, Shishuai, Zhang, Hongyu, Tian, Chunyan, Sun, Aihua, Wei, Handong, Zhang, Pumin, Wu, Yan, Jiang, Ying, He, Fuchu
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2018
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277559/
https://ncbi.nlm.nih.gov/pubmed/30266653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.08.016
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