Inhibiting Cycloxygenase and Ornithine Decarboxylase by Diclofenac and Alpha-Difluoromethylornithine Blocks Cutaneous SCCs by Targeting Akt-ERK Axis

Non-melanoma skin cancer (NMSC) is the most common type of skin cancer in Caucasian populations. Its increasing incidence has been a major public health concern. Elevated expressions of ODC and COX-2 are associated with both murine and human NMSCs. Inhibition of these molecular targets singly employ...

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Main Authors: Arumugam, Aadithya, Weng, Zhiping, Talwelkar, Sarang S., Chaudhary, Sandeep C., Kopelovich, Levy, Elmets, Craig A., Afaq, Farrukh, Athar, Mohammad
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832653/
https://ncbi.nlm.nih.gov/pubmed/24260338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080076
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