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Decarboxylation of alpha-difluoromethylornithine by ornithine decarboxylase.

The mechanism of inactivation of rodent ornithine decarboxylase by alpha-difluoromethylornithine (DFMO) was studied using the inhibitor labelled with 14C in both the 1 and the 5 positions. [1-14C]DFMO was a substrate and was decarboxylated by the enzyme yielding 14CO2. A radioactive metabolite deriv...

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Detalhes bibliográficos
Main Authors: Pegg, A E, McGovern, K A, Wiest, L
Formato: Artigo
Idioma:Inglês
Publicado em: 1987
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1147558/
https://ncbi.nlm.nih.gov/pubmed/3105526
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