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Human myeloma cells acquire resistance to difluoromethylornithine by amplification of ornithine decarboxylase gene.

Stepwise increments of the concentration of 2-difluoromethylornithine (DFMO), a mechanism-based irreversible inhibitor of mammalian ornithine decarboxylase (ODC), resulted in a selection of cultured human IgG-myeloma cells (Sultan cell line) capable of growing in the presence of up to 3 mM-DFMO. Thi...

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Detalhes bibliográficos
Main Authors: Leinonen, P, Alhonen-Hongisto, L, Laine, R, Jänne, O A, Jänne, J
Formato: Artigo
Idioma:Inglês
Publicado em: 1987
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1147683/
https://ncbi.nlm.nih.gov/pubmed/3109382
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