Cadaverine supplementation during a chronic exposure to difluoromethylornithine allows an overexpression, but prevents gene amplification, of ornithine decarboxylase in L1210 mouse leukaemia cells.

We recently selected a variant mouse L1210 leukaemia-cell line overproducing ornithine decarboxylase (ODC) (EC 4.1.1.17) as a result of chronic exposure to 2-difluoromethylornithine (DFMO) in the presence of micromolar concentrations of cadaverine. These cells, now grown for more than 2 years in the...

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Detalhes bibliográficos
Main Authors: Alhonen-Hongisto, L, Hirvonen, A, Sinervirta, R, Jänne, J
Formato: Artigo
Idioma:Inglês
Publicado em: 1987
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1148461/
https://ncbi.nlm.nih.gov/pubmed/3122732
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