Polyamine content of Pneumocystis carinii and response to the ornithine decarboxylase inhibitor DL-alpha-difluoromethylornithine.

Difluoromethylornithine (DFMO; eflornithine hydrochloride [Ornidyl]), a suicide inhibitor of the key polyamine biosynthesis enzyme ornithine decarboxylase (ODC), is effective in treating Pneumocystis carinii pneumonia, a common opportunistic infection associated with AIDS. Despite DFMO's specificity...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Merali, S, Clarkson, A B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163241/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8849262/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.4.973
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