Polyamine content of Pneumocystis carinii and response to the ornithine decarboxylase inhibitor DL-alpha-difluoromethylornithine.

Difluoromethylornithine (DFMO; eflornithine hydrochloride [Ornidyl]), a suicide inhibitor of the key polyamine biosynthesis enzyme ornithine decarboxylase (ODC), is effective in treating Pneumocystis carinii pneumonia, a common opportunistic infection associated with AIDS. Despite DFMO's specificity...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Merali, S, Clarkson, A B
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163241/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8849262/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.4.973
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