Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy

Acute Lymphoblastic Leukemia (ALL) remains the most frequent cause of cancer-related mortality in children and novel therapies are needed for the treatment of relapsed/refractory childhood ALL. One approach is the targeting of ALL blasts with the Pseudomonas immunotoxin CAT-8015. Although CAT-8015 h...

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Udgivet i:Front Oncol
Main Authors: Bokori-Brown, Monika, Metz, Jeremy, Petrov, Peter G., Mussai, Francis, De Santo, Carmela, Smart, Neil J., Saunders, Sarah, Knight, Bridget, Pastan, Ira, Titball, Richard W., Winlove, C. Peter
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277520/
https://ncbi.nlm.nih.gov/pubmed/30538953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00553
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