Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport

Posttranslational modifications of tubulin are emerging regulators of microtubule functions. We have shown earlier that upregulated polyglutamylation is linked to rapid degeneration of Purkinje cells in mice with a mutation in the deglutamylating enzyme CCP1. How polyglutamylation leads to degenerat...

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Publicado en:EMBO J
Main Authors: Magiera, Maria M, Bodakuntla, Satish, Žiak, Jakub, Lacomme, Sabrina, Marques Sousa, Patricia, Leboucher, Sophie, Hausrat, Torben J, Bosc, Christophe, Andrieux, Annie, Kneussel, Matthias, Landry, Marc, Calas, André, Balastik, Martin, Janke, Carsten
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2018
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276888/
https://ncbi.nlm.nih.gov/pubmed/30420556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100440
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