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IGF-1 and pAKT Signalling Promote Hippocampal CA1 Neuronal Survival Following Injury to Dentate Granule Cells.
Insulin-like growth factor-1 (IGF-1) protects neurons from apoptosis and in vivo offers neuroprotective support to hippocampal CA1 pyramidal neurons following ischemia or seizure. IGF-1 signals through IGF-1 receptors activating phosphytidylinositol 3-kinase (PI3K)/Akt or pMAPK pathways. IGF-1 can b...
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| Published in: | Neurotox Res |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6276784/ https://ncbi.nlm.nih.gov/pubmed/19526277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12640-009-9060-y |
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