The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell-free system, but not in human cells

The minimal vertebrate telomerase enzyme is composed of a protein component (telomerase reverse transcriptase, TERT) and an RNA component (telomerase RNA, TR). Expression of these two subunits is sufficient to reconstitute telomerase activity in vitro, while the formation of a holoenzyme comprising...

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Bibliografiske detaljer
Udgivet i:Cell Mol Biol Lett
Main Authors: Trapp-Fragnet, Laetitia, Marie-Egyptienne, Delphine T., Fakhoury, Johans, Rasschaert, Denis, Autexier, Chantal
Format: Artigo
Sprog:Inglês
Udgivet: SP Versita 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275662/
https://ncbi.nlm.nih.gov/pubmed/22941205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2478/s11658-012-0031-6
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