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Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain
Atomic resolution characterization of the full-length p53 tetramer has been hampered by its size and the presence of extensive intrinsically disordered regions at both the N and C termini. As a consequence, the structural characteristics and dynamics of the disordered regions are poorly understood w...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6275486/ https://ncbi.nlm.nih.gov/pubmed/30420502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814051115 |
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