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Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain

Atomic resolution characterization of the full-length p53 tetramer has been hampered by its size and the presence of extensive intrinsically disordered regions at both the N and C termini. As a consequence, the structural characteristics and dynamics of the disordered regions are poorly understood w...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Krois, Alexander S., Dyson, H. Jane, Wright, Peter E.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275486/
https://ncbi.nlm.nih.gov/pubmed/30420502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814051115
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