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Cryo-EM reveals ligand induced allostery underlying InsP(3)R channel gating
Inositol-1,4,5-trisphosphate receptors (InsP(3)Rs) are cation channels that mobilize Ca(2+) from intracellular stores in response to a wide range of cellular stimuli. The paradigm of InsP(3)R activation is the coupled interplay between binding of InsP(3) and Ca(2+) that switches the ion conduction p...
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| Veröffentlicht in: | Cell Res |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6274648/ https://ncbi.nlm.nih.gov/pubmed/30470765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-018-0108-5 |
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